Stem cell therapy can induce repair and/or regeneration of the failing myocardium and is a promising new approach for the treatment of heart failure. However, suboptimal cell-delivery route is a major issue. Any current method results in poor retention and survival of donor cells, limiting the therapeutic efficacy of the treatment. This lecture will summarise recent (pre-clinical and clinical) progress of stem cell therapy to the heart. In particular, advantages and disadvantages of current cell-delivery modes will be discussed and the methods to improve these approaches will be introduced. Utility of innovative bioengineering technologies for cell therapy, including epicardial placement of stem cells using cell-sheets generated with temperature-responsive culture dishes and other new methods, will also be introduced and discussed.