A new molecular imaging method that combines high MRI spatial resolution with high MRS molecular specificity is described. The platform is an ultra-high speed, high spatial resolution, 3D chemical shift imaging (CSI) mode called Biosensor Imaging of Redundant Deviation in Shifts (BIRDS). The detected signals are the paramagnetically-shifted and non-exchangeable protons from lanthanide or transition metal ion probes. These protons have extremely short relaxation times (i.e., high-speed CSI signal averaging) and their shifts are very sensitive ambient reporters (i.e., molecular sensing by CSI). Biomedical applications are discussed with mindset on sensitivity, toxicity, and translation.
The lecture will be at 5 pm at the UCL Institute of Neurology, 12 Queen Square, on the fourth floor at the Wellcome Trust Centre for Neuroimaging. All are welcome.