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Professor Brenda Banwell from the Children’s Hospital of Philadelphia and University of Pennsylvania is the guest speaker for February. She’ll be discussing ‘MRI in Paediatric multiple sclerosis: insights into the early aspects of MS’.
Conventional MRI sequences inform on visible inflammatory disease activity in multiple sclerosis (MS) and on the impact of MS on brain volume over time. Analyses of these parameters in paediatric MS patients demonstrates that the young age of paediatric MS patients neither protects them from aggressive inflammation nor from the degenerative aspects of MS pathobiology. The advent of more advanced imaging techniques has permitted interrogation of brain tissue microstructure in lesional and non-lesional tissue. Application in paediatric MS patients permits evaluation of whether loss of tissue integrity is an early aspect of MS. Data from recent studies of neuroimaging in paediatric MS cohorts will be presented to illustrate insights gained from conventional and advanced MRI analyses.