Loading Events

LGR5+ stem cells in epithelial renewal and cancer: Dr. Nick Barker

  • This event has passed.

The availability of robust cell-surface markers for identifying and isolating adult stem cells is essential for studying both their normal in-vivo function during tissue renewal and for evaluating their contribution to cancer. We have shown Lgr5, a Wnt target gene expressing a 7-TM receptor that functions as facultative component of the Wnt receptor complex, to selectively mark stem cells in a range of rapidly renewing tissues, including the small intestine, colon, stomach, hair follicle, ovary and developing kidney. Multicolor lineage tracing employing the stem cell-specific Lgr5-CreERT2 line has been used to further dissect how these adult stem cell pools maintain tissue homeostasis and contribute to tissue repair following damage. Targeted in-vivo mutation of the Lgr5+ve adult stem cell pools using the same Lgr5-CreERT2 model has been used to determine the contribution of stem cells to tumor initiation and progression in the gut. A summary of this work will be presented here.


UCL Ear Institute


Main Lecture Theatre, UCL Ear Institute
332 Grays Inn Rd, London, WC1X 8EE United Kingdom
+ Google Map

Cookies on IBME website

Our website uses cookies to provide us with important information about visitors. By continuing to browse the site we'll assume that you are happy to receive all cookies set by IBME.