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Flow detection and calcium signaling in vascular endothelial cells: Dr. Kimiko Yamamoto

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Endothelial cells (ECs) lining blood vessel walls respond to shear stress, a fluid mechanical force generated by flowing blood, and the EC responses play a important role in the homeostasis of the circulatory system.  Abnormal EC responses to shear stress impair various vascular functions and lead to vascular diseases, including hypertension, thrombosis, and atherosclerosis.  Bio-engineering approaches in which cultured ECs are subjected to shear stress in fluid-dynamically designed flow-loading devices have been widely used to analyze EC responses at the cellular and molecular levels. Remarkable progress has been made, and the results have shown that ECs alter their morphology, function, and gene expression in response to shear stress.  Shear stress affects immature cells as well as mature ECs, and it promotes differentiation of bone-marrow-derived endothelial progenitor cells and embryonic stem cells into ECs.  Much research has been done on shear stress sensing and signal transduction, and their molecular mechanisms are gradually coming to be understood.  However, much remains uncertain, and many candidates have been proposed for shear stress sensors.  More extensive studies of vascular mechanobiology should increase our understanding of the molecular basis of the blood-flow-mediated control of vascular functions.

Academic Career:

1996-2000 Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo (M.D.)

1993-1996  Department of Materials Science and Engineering, Graduate School of Engineering, Yamagata University (Dr. of Eng.)

1987-1989  Department of Applied Chemistry, Graduate School of Science and Engineering, Waseda University (M.E.)

1983-1987  Department of Applied Chemistry, Faculty of Science and Engineering, Waseda University

Professional Career:

2003-Current  Lecturer: Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo

2006-2010  Research Fellow: PRESTO, Japan Science and Technology Agency

2000-2003  Assistant Professor: Department of Biomedical Engineering Graduate School of Medicine, The University of Tokyo

1997-2000  Research Fellow: Japan Society for the Promotion of Science (JSPS)

1989-1992  Chemist: Central Research Center, Du Pont Japan, Ltd.


September 23, 2013
2:00 pm - 3:00 pm


Imperial, South Kensington
South Kensington Campus, Imperial, Exhibition Road, London, SW7 2AZ United Kingdom
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UCL Department of Bioengineering

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