UCL INSTITUTE OF BIOMEDICAL ENGINEERING
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Engineering the artificial pancreas: Prof Roger W. H. Sargent

December 5, 2013 @ 5:30 pm - 6:30 pm

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease affecting approximately 35 million individuals world-wide, with associated annual healthcare costs in the US estimated to be approximately $15 billion. Current treatment requires either multiple daily insulin injections or continuous subcutaneous (SC) insulin infusion (CSII) delivered via an insulin infusion pump. Both treatment modes necessitate frequent blood glucose measurements to determine the daily insulin requirements for maintaining near-normal blood glucose levels.

More than 30 years ago, the idea of an artificial endocrine pancreas for patients with type 1 diabetes mellitus (T1DM) was envisioned. The closed-loop concept consisted of an insulin syringe, a blood glucose analyzer, and a transmitter. In the ensuing years, a number of theoretical research studies were performed with numerical simulations to demonstrate the relevance of advanced process control design to the artificial pancreas, with delivery algorithms ranging from simple PID, to H-infinity, to model predictive control. With the advent of continuous glucose sensing, which reports interstitial glucose concentrations approximately every minute, and the development of hardware and algorithms to communicate with and control insulin pumps, the vision of closedloop control of blood glucose is approaching a reality.

In the last 10 years, our research group has been working with medical doctors on clinical demonstrations of feedback control algorithms for the artificial pancreas. In this talk, I will outline the difficulties inherent in controlling physiological variables, the challenges with regulatory approval of such devices, and will describe a number of process systems engineering algorithms we have tested in clinical experiments for the artificial pancreas

Details

Date:
December 5, 2013
Time:
5:30 pm - 6:30 pm

Venue

Chemical Engineering Lecture Theatre 1, ACEX Extension
South Kensington Campus, Exhibition Road, London, SW7 2AZ United Kingdom
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Organizer

Imperial Department of Chemical Engineering
Email:
Website:
http://www3.imperial.ac.uk/chemicalengineering

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