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Even at their earliest stages, human cancers are more than just cells with malignant potential. Cells and extracellular matrix components that normally support and protect the body are coerced into a tumour microenvironment that is central to disease progression. The hypothesis of the CANBUILD project is that recent advances in tissue engineering, biomechanics and stem cell biology make it possible to engineer, for the first time, a complex 3D human tumour microenvironment in which individual cell lineages of malignant, haemopoietic and mesenchymal origin will communicate, evolve and grow in vitro. The ultimate aim is to build this cancerous tissue with autologous cells as there is an urgent need for models in which we can study the interaction of human immune cells with malignant cells from the same individual in an appropriate 3D biomechanical microenvironment.
The CANBUILD project comprises a multi-disciplinary team of collaborators with international standing in tumour microenvironment research, cancer treatment, tissue engineering, mechanobiology, stem cell research and 3D computer-assisted imaging.
The goal is to recreate the microenvironment of high-grade serous ovarian cancer metastases in the omentum. We have focused on this major clinical problem because we have extensive knowledge of the microenvironment of this cancer and we have already established simple 3D models of these metastases.
The research plan involves:
• Deconstruction of this specific tumour microenvironment
• Construction of artificial scaffold, optimising growth of cell lineages, assembly of the model
• Comparison to fresh tissue
• Investigating the role of individual cell lineages
• Testing therapies that target the tumour microenvironment
Our vision is that this project will revolutionise the practice of human malignant cell research, replacing inadequate and misleading systems based on cancer cell monoculture on plastic surfaces and allowing us to better test new treatments that target the human tumour microenvironment.
SEMS/IoB Seminar Series
Coffee/tea/biscuits provided after the seminar